RecruitingNCT06160596

Analyzing and Solving Exceptional Long-term Survivors in Solid Tumors With Poor Prognosis

Analyzing and Solving Exceptional Long-term Survivors in Solid Tumors With Poor Prognosis: A 3 Cohorts Case Control Matched Study


Sponsor

Cure 51

Enrollment

1,020 participants

Start Date

Nov 1, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

This is a retrospective, exploratory, multi-center, translational, 3 cohorts case control matched study conducted in patients harboring a solid tumor with poor prognosis who presented a long-term (case) and standard (standard) survival. Patients with: * Cohort A: metastatic pancreatic ductal adenocarcinoma * Cohort B: glioblastoma IDHwt * Cohort C: extensive small cell lung cancer This research aims to integrate data generated from clinical records, imaging, multi-omics and bioinformatics approaches to discriminate case and control and then to identify new therapeutic targets. Analyses will be performed depending on the tumor samples available with at least 3 omics levels and according to scientific advances; genomic, epigenomic, proteomics, metabolomics, transcriptomic, microbiomic.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at patients who have survived unusually long after being diagnosed with cancers that typically have very poor outcomes — specifically metastatic pancreatic cancer, glioblastoma (a brain cancer), and extensive small cell lung cancer. By studying these "exceptional survivors," researchers hope to discover what biological or genetic factors allowed them to live so much longer than expected. **You may be eligible if...** - You are 18 years or older at the time of your cancer diagnosis - You have been diagnosed with metastatic pancreatic cancer, glioblastoma (IDH-wildtype), or extensive small cell lung cancer - You have survived at least 5 years from a stage IV diagnosis (for pancreatic and lung cancer) or at least 3 years (for glioblastoma) - Stored tumor tissue and clinical records from your diagnosis are available **You may NOT be eligible if...** - You have not reached the required survival threshold - You do not have one of the three qualifying cancer types - Required tumor tissue samples or clinical records are not available Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICLong term survival multimodal analysis

* To describe global signatures (Digital histology, Radiomic, Genomic, Transcriptomic, Proteomic, (Epigenomic) and clinical signature) that are associated with a patient's unexpected survival compared to standard patients across three cohorts of solid tumors with unmet medical needs. * To describe global signatures in the overall population (pan-cohort). * To describe clinical, digital pathology, radiomic, genomic, transcriptomic, proteomic and epigenomic signatures associated with patients' unexpected survival compared to standard patients for each cohort and in all cohorts (pan-cohort)


Locations(1)

Gustave Roussy Cancer Campus, Grand Paris

Villejuif, France

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NCT06160596


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