RecruitingNCT06160635

D-SOLVE Cohorts (Cohort a and B)


Sponsor

Hannover Medical School

Enrollment

750 participants

Start Date

Feb 22, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Hepatitis D is by far the most severe form of chronic viral hepatitis, frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection Hepatitis D is caused by co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV). This multicenter cohort should enable a comprehensive and unbiased biomarker screening of well-defined HDV-infected patients, followed by mechanistic studies to determine the functional role of distinct molecules. Patient surveillance strategies and antiviral treatment approaches could be personalized which should reduce clinical and social disease burden, improve quality of life and save direct and indirect costs caused by HDV infection.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Anti-HDV positive
  • ≥18 years old
  • Sex: m/f/d
  • Informed consent for prospective procedures

Exclusion Criteria1

  • Anti-HDV negative

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Locations(4)

Hannover Medical School, Department of Gastroenterology, Hepatology, Infectious Disease and Endocrinology

Hanover, Germany

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (University of Milan)

Milan, Italy

Institutul de Boli Infectioase "Prof. Dr. Matei Bals"

Bucharest, Romania

Karolinska University Hospital and Karolinska Institutet

Stockholm, Sweden

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NCT06160635


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