RecruitingNCT06161285

Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants


Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

120 participants

Start Date

Dec 6, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.


Eligibility

Min Age: 1 DayMax Age: 12 Months

Inclusion Criteria5

  • Infants <12 months
  • With bronchiolitis during RSV epidemic season
  • No chronic illness
  • No bronchiolitis medical history
  • Signed consent from parents or legal guardians

Exclusion Criteria4

  • Chronic respiratory illness
  • Medical history of bronchiolitis or newborn asthma
  • Treatment with immunosuppressants
  • Patient with no social security affiliation

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Interventions

OTHERSampling

Single-time sampling of respiratory virus-infected children


Locations(3)

APHP, Antoine Béclère Hospital

Clamart, France

AP-HP,Raymond Poincaré Hospital

Garches, France

Réanimation médico-chirurgicale Necker

Paris, France

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NCT06161285


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