Submental Flap for the Reconstruction of Hypopharyngectomy
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
40 participants
Feb 16, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this observational study is to assess the safety and efficacy of submental artery island flap (SMAIF) in the reconstruction of laryngeal and hypopharyngal defects after the surgical resection of hypopharyngeal cancer. The main questions it aims to answer are: * The survival of SMAIF and the recovery of laryngeal function. * The oncologic outcomes of SMAIF comparing with other reconstructions or radiotherapy. Participants will underwent partial laryngectomy and hypopharyngectomy and reconstruction of SMAIF. Postoperative adjuvant radiotherapy will be recommented when adverse pathologic features were noted.
Eligibility
Inclusion Criteria4
- T2-T3 hypopharyngeal squamous cell carcinoma located in the piriform sinus or posterior hypopharyngeal wall cancer;
- The contralateral hemilarynx is mobile;
- the Eastern Cooperative Oncology Group (ECOG) performance status (PS) score was 0 or 1;
- Without a history of radiotherapy.
Exclusion Criteria5
- Invasion into the cricoid cartilage and unable to reserve the larynx；
- Pulmonary insufficiency, FEV1/FVC\<50%;
- Unresctable neck diseases including carotid artery envoloped or tumor penetration to the prevertebral fascia or mediastinum;
- Heart insufficincy whice intolerate to general anesthesia;
- With distant metastasis.
Interventions
submental artery island flap (SMAIF) for the reconstruction of laryngeal and hypopharyngal defects after the surgical resection of hypopharyngeal cancer
Locations(1)
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NCT06161779