RecruitingNot ApplicableNCT06166199

Effects of High-intensity Interval Training in Patients With Systemic Lupus Erythematosus

Effects of High-intensity Interval Training Combined With Resistance Training in Patients With Systemic Lupus Erythematosus

Sponsor

Karolinska Institutet

Enrollment

40 participants

Start Date

Nov 1, 2022

Study Type

INTERVENTIONAL

Conditions

Lupus Erythematosus, Systemic

Summary

The aim of this study is to evaluate the safety and effects of high-intensity interval training (HIIT) combined with resistance training in patients with systemic lupus erythematosus

Eligibility

Min Age: 18 Years

Inclusion Criteria7

≥18 years old
Fulfilment of the 1982 American College of Rheumatology (ACR) criteria; or 2012 Systemic Lupus International Collaborating Clinics (SLICC/ACR-Damage Index (DI)) classification criteria; or EULAR/ACR criteria; or patients that have received the diagnosis SLE on clinical grounds
Low to moderate disease activity, for example defined as a score of ≤5 in the clinical version of the SLE Disease Activity Index 2000 (SLEDAI-2K), i.e., excluding the serological descriptors (anti-dsDNA positivity and low complement levels)
Low/minimal or no organ damage, for example defined as a score of ≤3 in the SLICC/ACR DI
Stable pharmacological treatment
The ability to perform a maximal ergometercycle exercise test
Be able to read and understand Swedish

Exclusion Criteria6

Symptoms or signs of cerebro-vascular disease, pulmonary embolus, pulmonary hypertension, pulmonary fibrosis, cardiovascular disease, angina pectoris, myocardial infarction, dyspnea at rest, uncontrolled blood pressure and uncontrolled diabetes within one year prior to study entry. Chronic kidney disease with
Patients who fulfil the absolute contraindications for maximal exercise testing according to American Heart Association
Patients who cannot perform a maximal ergometercycle exercise test due to the disease
Diseases or other conditions that strongly reduce the ability to exercise or that exercise is not recommended
Patients who perform regular aerobic fitness training and muscle strength exercise sessions at fixed times, \>1 time/week
Pregnancy

Interventions

BEHAVIORALHIIT combined with resistance training

Patients with SLE will undergo supervised HIIT on an ergometercycle, 4 x 4 minutes interval, (85-90% of maximal heart rate in 4 minutes and lower intensity for another 4 minutes etc). The HIIT is combined with resistance exercises for upper and lower extremity. In total the training takes around 50 minutes per occasion and will be performed 2 times/week, for 3 months. In addition, the patients will exercise, according to the program, by themselves once a week. Between months 3 and 6 the patients exercise by themselves, 3 times/week, with video-call/telephone support from a physiotherapist once a week.