RecruitingNot ApplicableNCT06167057

POST URS Chemotherapy Instillation

Single Bladder Instillation With Chemotherapy Following Endoscopic Treatment for Upper Tract Urothelial Carcinoma to Reduce Bladder Recurrence


Sponsor

Carmel Medical Center

Enrollment

264 participants

Start Date

Apr 17, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to evaluate the safety and oncological outcomes of single chemotherapy bladder instillation following endoscopic treatment for UTUC in UTUC suspected patients .The main aim is to determine the efficacy of a single, post URS, chemotherapy bladder instillation to reduce IVR. Participants will be given single chemotherapy bladder instillation within 24h following ureteroscopy and will follow routine follow-up for IVR which will include white light cystoscopy ;patients with suspected IVR (based on either imaging or cystoscopy) will undergo TURBT.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Mitomycin/Gemcitabine and a drug called Saline for people with utuc. The study is currently recruiting participants at 10 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMitomycin/Gemcitabine

UTUC treatment

DRUGSaline

UTUC treatment


Locations(10)

Assuta Ashdod Hospital

Ashdod, Israel

Soroka University Medical Center

Beersheba, Israel

Shamir Medical Center

Be’er Ya‘aqov, Israel

Bnai Zion Medical Center

Haifa, Israel

Carmel Medical Center

Haifa, Israel

Rambam Health Care Campus

Haifa, Israel

Rabin Medical Center - Beilinson and Hasharon

Petah Tikva, Israel

Kaplan Medical Center

Rehovot, Israel

Ziv Medical Center

Safed, Israel

Tel Aviv Sourasky Medical Center - Ichilov

Tel Aviv, Israel

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NCT06167057


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