Telmisartan in Prostate Cancer

This study is testing whether adding telmisartan — a common blood pressure drug — alongside standard prostate cancer treatment can improve outcomes. Lab studies suggest telmisartan may help cancer drugs work better. **You may be eligible if...** - You are 18 or older with prostate cancer that is being treated with specific standard regimens (including docetaxel, cabazitaxel, olaparib, rucaparib, or talazoparib plus enzalutamide) - Your cancer is stable or progressing on PSA but without requiring an immediate change in treatment - You have adequate liver and kidney function - Your standing blood pressure is at least 110 mmHg systolic - You have testosterone at castrate levels (if not on active surveillance) **You may NOT be eligible if...** - You have a contraindication to telmisartan (including recent ACE inhibitor use in the last 6 weeks) - Your blood pressure is too low to safely take telmisartan throughout the study Talk to your doctor to see if this trial is right for you.