RecruitingNCT06169540

Salivary Extracellular Vesicle Associated lncRNAs in Heart Failure (SEAL-HF)


Sponsor

Massachusetts General Hospital

Enrollment

90 participants

Start Date

Apr 19, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to determine the relationship between the levels of Ribonucleic acid (RNA) circulating molecules, including ones in extracellular vesicles from different organs in the blood and in the saliva of patients with Acute Decompensated Heart Failure (ADHF) and Chronic Heart Failure (CHF) to see if a new, non-invasive diagnostic test can be developed for heart failure exacerbation.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking for molecular markers (specifically certain types of genetic material) in saliva that might help doctors diagnose and monitor heart failure — potentially offering a simpler alternative to blood tests or invasive procedures. **You may be eligible if...** - You are 18 or older - You have been diagnosed with chronic heart failure (any type, with symptoms ranging from mild to severe) OR you have acute (sudden severe) heart failure currently being treated, OR you are having a heart procedure in the EP (electrophysiology) lab and can serve as a comparison participant **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have cardiac amyloidosis (a specific type of heart disease) - You have an active cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Massachusetts General Hospital

Boston, Massachusetts, United States

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NCT06169540


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