RecruitingNCT06171958

Incidence of Acute Kidney Injury After Administration of Iodine Contrast Media in Patients With Reduced Renal Function

Cohort Study of Intravenous Contrast-media Influence on Decreased Renal Function


Sponsor

Uppsala University

Enrollment

400 participants

Start Date

Jan 24, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This study is examining if injection of iodine contrast media increases the risk of acute kidney injury in patients with severely reduced renal function. All patients who have a medical need for a computerized tomography, either with or without iodine contrast media, and has a renal function of less than estimated glomerular filtration rate (eGFR) 30 will be recruited. Blood and urine samples will be collected at baseline, three and 21 days after the computerized tomography. Additionally, we will examine if the decision to use iodine contrast media or not was easy or difficult if the use of iodine contrast media potentially changed the patient care and if it might have been lifesaving.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • eGFR <30 mL/min/1.73m2, calculated with the revised Lund-Malmö formula and plasma creatinine.
  • Medical need of either an ICM-enhanced or unenhanced CT

Exclusion Criteria4

  • <18 years of age
  • Ongoing renal replacement therapy
  • Ongoing treatment with nephrotoxic drugs. Drugs classified as nephrotoxic are acyclovir, aminoglycosides, ciclosporins, cisplatin, methotrexate, non-steroidal anti-inflammatory drugs (except low-dose aspirin) and vancomycin administered intravenously.
  • Known allergy to ICM who and have not received prophylactic treatment (if patient belongs to ICM arm)

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Interventions

DRUGIodine-containing Contrast Media

Patients will receive or not receive ICM depending on their medical need.


Locations(1)

Uppsala University

Uppsala, Sweden

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NCT06171958