Immunotherapy in Combination With Chemoradiotherapy in Unresectable Locally Advanced Esophageal Cancer

This trial is testing whether adding immunotherapy (a drug that helps the immune system fight cancer) to standard chemoradiation treatment — chemotherapy plus radiation given together — improves outcomes for people with locally advanced esophageal cancer that cannot be surgically removed. **You may be eligible if...** - You are between 18 and 75 years old with locally advanced esophageal cancer that cannot be surgically removed (or you have chosen not to have surgery) - You have not had any prior cancer treatment (no chemotherapy, radiation, immunotherapy, or surgery for esophageal cancer) - You have adequate blood counts, lung, heart, kidney, and liver function - You have an ECOG performance status of 0-1 (able to carry out normal daily activities) **You may NOT be eligible if...** - You have had another cancer in the past 5 years - Your doctor believes you are at high risk of esophageal bleeding, fistula (abnormal hole), or perforation - You have autoimmune disease or are on immune-suppressing medications Talk to your doctor to see if this trial is right for you.