RecruitingNCT06174233

The French Gut-colo

"Contribution of Metagenomic Analysis of Faecal Microbiota Combined With Artificial Intelligence for the Prediction of Colorectal Cancer Risk; Study in Patients Scheduled for Colonoscopy".

Sponsor

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Enrollment

2,500 participants

Start Date

Jun 26, 2024

Study Type

OBSERVATIONAL

Conditions

Patients Aged 50-75 and Requiring Colonoscopy

Summary

Colorectal cancer (CRC) is the second most common type of cancer worldwide. The European Union recommends national CRC screening for people aged between 50 and 74. Generally, an immunological test called FIT (Fecal Immunochemical Test), based on the quantitative detection of human haemoglobin, is performed on a stool sample. If the haemoglobin level is above the recommended threshold, a colonoscopy is recommended to detect colorectal lesions. Recent studies have identified potential microbiota signatures associated with colon cancer. In this study, we will analyze the microbiota of a population aged 50 to 75 years undergoing colonoscopy as part of routine care in order to confirm the presence of microbiota signatures associated with the presence of adenomas, advanced adenomas and CRC.

Eligibility

Min Age: 50 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This French study (called Gut-colo) is comparing gut microbiome analysis (studying bacteria in your stool) with standard colorectal cancer screening tests to see whether gut bacteria patterns can predict who is more likely to have polyps or cancer found on colonoscopy. **You may be eligible if...** - You are between 50 and 75 years old - You are already scheduled to have a colonoscopy - You are able to provide a stool (fecal) sample and take a home stool blood test (FIT test) before your colonoscopy - You do not have a known inflammatory bowel disease (like Crohn's disease or ulcerative colitis) - You live in France **You may NOT be eligible if...** - You do not live in France - You have inflammatory bowel disease - You have participated in a clinical research study involving an investigational drug within the past 60 days Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Hopital Avicenne, Centre de Recherche sur Volontaire

Bobigny, France

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NCT06174233