RecruitingPhase 1Phase 2NCT06176027

Azacytidine Plus CAOLD Regimen in Relapsed/Refractory Peripheral T-Cell Lymphomas

Therapeutic Effect of Chemotherapy Azacytidine Plus CAOLD Regimen on Patients With Relapsed/Refractory Peripheral T-Cell Lymphomas


Sponsor

Navy General Hospital, Beijing

Enrollment

52 participants

Start Date

Oct 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a multicenter prospective single arm phase II study. The purpose of this study is to evaluate the safety and efficiency of azacytidine combined with CAOLD Regimen in the treatment of relapsed/refractory peripheral t-cell lymphomas.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a combination regimen of azacytidine plus the CAOLD chemotherapy drugs for people with angioimmunoblastic T-cell lymphoma (AITL) — a specific type of T-cell lymphoma — that has come back or stopped responding to at least one prior treatment. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of angioimmunoblastic T-cell lymphoma (AITL) - Your lymphoma has relapsed after, or never responded to, at least one prior round of systemic therapy - Your blood counts meet the minimum required levels (white cells, platelets) - You are willing to commit to the study visit schedule **You may NOT be eligible if...** - You have active, uncontrolled infections - You have significant liver, kidney, or heart problems that make chemotherapy unsafe - You have another active malignancy - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAzacytidine plus CAOLD regimen

Patients were treated by Azacytidine(75 mg/m2 on days 1-7) plus CAOLD regimen (cyclophosphamide 400mg/m2 qd d1; cytarabine 30mg/m2 qd d1-d4; vindesine 2mg/m2 qd d1; pegaspargase 2500iu/m2 qd d2; dexamethasone 7.5mg/m2 qd d1-d5)


Locations(1)

Navy General Hospital

Beijing, Beijing Municipality, China

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NCT06176027