Lerapolturev (PVSRIPO) in GBM

This trial is testing lerapolturev (also called PVSRIPO) — a modified poliovirus injected directly into the brain tumor — for people with recurrent glioblastoma (the most aggressive and deadly brain cancer) that has come back after standard treatment, including surgery, radiation, and chemotherapy. **You may be eligible if...** - You are 18 or older with confirmed recurrent glioblastoma (brain tumor) that has come back after prior treatment - You have a good performance score (Karnofsky 70% or higher) - You have adequate blood counts, kidney, and liver function - Your tumor is located in the cerebral hemispheres (not the brainstem) and is accessible for injection **You may NOT be eligible if...** - You have not yet tried standard treatments like surgery, radiation, and temozolomide chemotherapy - You have known allergy to polio vaccine - You have received a polio booster vaccine within the past year (you would need to get one before enrolling) - Your tumor involves the brainstem or other areas that cannot be safely accessed Talk to your doctor to see if this trial is right for you.