RecruitingNot ApplicableNCT06179329

One-year Patency Comparison Between Radial Artery and No-touch Saphenous Vein Grafts in Women Undergoing Isolated CABG

No-Touch Saphenous Venous Harvesting TechniQue versUs Radial artEry in Coronary Artery Bypass Grafting in womEN: The QUEEN Multicenter Randomized Controlled Trial

Sponsor

University of Sao Paulo General Hospital

Enrollment

150 participants

Start Date

Jan 1, 2024

Study Type

INTERVENTIONAL

Conditions

Cardiac Disease Surgery--Complications Graft Failure

Summary

The use of a graft from the left internal thoracic artery to the left anterior descending artery has become the gold standard for the indication of coronary artery bypass grafting. However, choosing a graft for the second-best coronary artery, focusing on long-term patency, is still a challenge. The saphenous vein using the "no-touch" technique is an alternative to a radial artery graft, but there is little evidence, especially in women. This randomized clinical study aims to compare the patency of these grafts in the second-best coronary artery in women undergoing coronary artery bypass grafting.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study compares two types of blood vessel grafts used in open heart bypass surgery (CABG) for women: one taken from the wrist (radial artery) and one taken from the leg using a special gentle technique that keeps the surrounding tissue intact (no-touch saphenous vein). Researchers want to see which graft stays open and working better after one year. **You may be eligible if...** - You are a woman between 18 and 74 years old - You need heart bypass surgery for the first time (not a repeat surgery) - You have blockages in all three main heart arteries - Your heart is pumping reasonably well (normal or near-normal ejection fraction) **You may NOT be eligible if...** - You have had a recent heart attack (within 24 hours) - You need emergency surgery - You have had prior heart surgery - You have certain other heart conditions such as severe valve disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURECoronary artery bypass graft

Randomization will be performed for stratification according to the target coronary arteries and the randomly determined block size from 4 to 6. The randomization result will be delivered in a sealed envelope in the operating room (before the time out) for one of the two drawn strategies.