2015-Metabolomics&Microbiome-infertility
Microbiome and Metabolomics Analysis in a Population of Infertile Patients Suffering From Non-obstructive Azospermia and Examination of Their Impact on the Reproductive Potential and Global Health of the Individual
IRCCS San Raffaele
45 participants
Jun 1, 2016
OBSERVATIONAL
Conditions
Summary
The study aims to carry out a translational analysis of the microbiome and metabolomics in patients suffering from non-obstructive azoospermia, with the aim of investigating prognostic factors predictive of the possible finding of spermatozoa following testicular pulp extraction and differences in blood and seminal level with the fertile population to identify etiopathogenic pathways of this condition.
Eligibility
Inclusion Criteria3
- diagnosis of idiopathic non-obstructive azoospermia
- fertile men (pregnancy within 12 months from the start of the couple's search)
- men known to have been fertile aged between 65 and 75 (pregnancy within 12 months of the couple starting searching)
Exclusion Criteria4
- diagnosis of varicocele
- endocrine alterations
- chromosomal alterations
- known genetic alterations
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Interventions
Analysis of microbiome and metabolomics through the assessment of blood and semen parameters
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06181851