The Prognostic Value of the Degree of Pathological Response of Induction Chemotherapy for NPC

This study looks at whether the degree to which nasopharyngeal carcinoma (NPC) — a cancer at the back of the nose and throat — responds to chemotherapy given before radiation treatment (induction chemotherapy) can predict how well patients will do long-term. Researchers want to use this response as a guide for personalizing future treatments. **You may be eligible if...** - You are over 18 years old - You have a confirmed diagnosis of locally advanced NPC (Stage III or IVa) - Your overall health allows you to tolerate chemotherapy and radiation (ECOG 0-1) - You are willing to follow the full study protocol **You may NOT be eligible if...** - Your NPC is at an early stage (I or II) or has spread distantly (Stage IVb) - You have serious heart, kidney, liver, or bone marrow problems - You have had prior chemotherapy or radiation for NPC - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.