Liposomal Irinotecan and Leucovorin/5-fluorouracil Plus Bevacizumab in Metastatic Colorectal Cancer

This study tests a combination of chemotherapy drugs — liposomal irinotecan, leucovorin, 5-fluorouracil, and bevacizumab — as a second-line treatment for people with colorectal cancer that has spread to other parts of the body and cannot be removed by surgery. **You may be eligible if...** - You are between 18 and 75 years old - You have colorectal cancer confirmed by biopsy or lab test - Your cancer has spread and cannot be surgically removed - You have already received first-line chemotherapy that included oxaliplatin - You are in reasonably good health (able to carry out daily activities with minimal limitations) **You may NOT be eligible if...** - Your cancer has not been previously treated - You have serious heart, liver, or kidney problems - You are pregnant or breastfeeding - You have already tried bevacizumab or irinotecan Talk to your doctor to see if this trial is right for you.