RecruitingPhase 2NCT06186726

Clinical Study of Carbon Ion Radiotherapy Combined With Chemotherapy for Thymic Epithelial Tumors

Prospective Phase II Clinical Study of Carbon Ion Radiotherapy Combined With Chemotherapy for Thymic Epithelial Tumors

Sponsor

Jian Chen

Enrollment

48 participants

Start Date

Jan 26, 2024

Study Type

INTERVENTIONAL

Conditions

Carbon Ion Radiotherapy, Thymoma, Thymic Carcinoma, Radiotherapy, Chemotherapy

Summary

To observe the efficacy of carbon ion radiotherapy combined with chemotherapy in the treatment of inoperable locally advanced or advanced (all visible lesions can be included in the radiation target area in this treatment) primary thymic epithelial tumor who have no thorax radiotherapy histroy. The patients will receive 72GyE/18fractions of carbon ion radiotherapy. Combined with platinum-containing schemes (including etoposide combined with cisplatin or carboplatin or loplatin or nedaplatin, paclitaxel combined with cisplatin or carboplatin or loplatin or nedaplatin, etc.); Docetaxel combined with cisplatin or carboplatin or loplatin or nedaplatin) for at least 4 cycles. Progression-free survival, local control rate, overall survival and toxicity were calculated.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This trial tests a combination of carbon ion radiotherapy (an advanced, precise type of radiation using carbon ions instead of X-rays) and chemotherapy for people with thymic epithelial tumors (cancers of the thymus gland) that cannot be surgically removed. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with a locally advanced or advanced thymic epithelial tumor confirmed by biopsy - Your cancer cannot be surgically removed - You have not previously received chest radiation therapy - Your tumor can be fully included in the radiation treatment area **You may NOT be eligible if...** - You have already had thoracic (chest) radiation therapy - Your cancer cannot be fully targeted with radiation - You have serious heart, liver, kidney, or lung problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONcarbon ion radiotherapy

The patients received 72GyE/18 doses of carbon ion radiotherapy.

Locations(1)

Shanghai Proton and Heavy Ion Center

Shanghai, Shanghai Municipality, China

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NCT06186726