A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors

This first-in-human study tests a new experimental drug called AZD8421 — alone or in combination with other treatments — in women with advanced or metastatic solid tumors. The primary goal is to assess safety and find the right dose. **You may be eligible if...** - You are a woman aged 18 or older - You have an advanced solid tumor (cancer that has spread and does not respond to standard treatment, or where a clinical trial is the best option) - You have received prior standard-of-care treatment for your cancer type - Your overall health meets required standards **You may NOT be eligible if...** - You are male (this trial enrolls female participants only) - You have active brain metastases that are untreated or unstable - You have serious heart, liver, or kidney conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.