RecruitingNot ApplicableNCT06188767

Testosterone-induced Muscle Memory and Underlying Mechanisms

Long-term Effects of Anabolic Androgenic Steroids on Muscle Growth Potential: Testosterone-induced Muscle Memory and Underlying Mechanisms


Sponsor

Morten Hostrup, PhD

Enrollment

30 participants

Start Date

Apr 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.


Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 40 Years

Inclusion Criteria2

  • Healthy men and women
  • BMI of <26 and normal ECG and blood pressure

Exclusion Criteria6

  • Smoking
  • Chronic disease,
  • Use of prescription medication
  • Pain due to current or previous musculoskeletal injury
  • Resistance training more than once per week in the 12 months leading up to the intervention
  • Current or previous use of prohibited anabolic substances

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Interventions

DRUGTestosterone Undecanoate

Following testosterone/placebo injection, participants undergo supervised resistance training for 4 weeks. This period is followed by a washout period with no drug and either continued resistance training or detraining for 16 weeks. Thereafter, another 4-week period with supervised resistance training is commenced, with no drug.


Locations(1)

The August Krogh Section for Human and Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen

Copenhagen, Denmark

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NCT06188767