RecruitingPhase 2NCT06190067

Azacitidine Plus PD-1 Therapy for R/R Hodgkin Lymphoma

Azacitidine Plus PD-1 Therapy for Relapsed/Refractory Hodgkin Lymphoma


Sponsor

Navy General Hospital, Beijing

Enrollment

40 participants

Start Date

Oct 30, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this phase 2 trial is to test the safety and efficacy of azacitidine when given together with PD-1 therapy in treating patients with relapsed/refractory classic Hodgkin lymphoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of azacitidine (a chemotherapy drug) plus a PD-1 checkpoint inhibitor (an immunotherapy) for people with Hodgkin lymphoma that has come back or stopped responding to treatment. **You may be eligible if...** - You are 18 or older - You have been diagnosed with Hodgkin lymphoma that has relapsed (came back) or is refractory (did not respond) after at least one prior treatment - Your blood counts meet minimum thresholds (neutrophils, platelets, hemoglobin) - Your estimated life expectancy is at least 3 months **You may NOT be eligible if...** - You have an active serious infection requiring IV antibiotics - You have severe heart, liver, kidney, or metabolic disease - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAzacitidine Plus PD-1 therapy

Patients were treated by Azacytidine(75 mg/m2 subcutaneous injection qd on days 1-7) plus PD-1 therapy(200mg iv qd d8)


Locations(1)

Navy General Hospital

Beijing, Beijing Municipality, China

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NCT06190067


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