RecruitingNot ApplicableNCT06190756

Impact of Gravity on Cardiac Hemodynamics

Effect of Intra-cardiac Hydrostatic Pressure Gradient in Cardiac Filling and Ejection

Sponsor

University Hospital, Caen

Enrollment

32 participants

Start Date

Nov 22, 2023

Study Type

INTERVENTIONAL

Conditions

Healthy Diabetes type1

Summary

The goal of this clinical trial is to define and compare pre-load dependance of the cardiac function according to the intracardiac hydrostatic gradient of pressure in healthy and diabetic populations. Participants will undergo 4 tilt angle and 4 lower body negative pressure intensities during which cardiovascular data will be assessed and a transthoracic echography will be performed.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Cardiovascular and Baroreflex stimulation by Lower Body Negative Pressure and Cardiovascular and Baroreflex stimulation by Tilting for people with diabetes type1 and healthy. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERCardiovascular and Baroreflex stimulation by Tilting

Tilt of the patient at 4 angles (22°, 42°, 58° and 80°), the order is randomized for 3 angles (22°, 42°, 58°) while 80° will always be last.

OTHERCardiovascular and Baroreflex stimulation by Lower Body Negative Pressure

The patient will undergo 4 level of LBNP (10Torr, 20Torr, 35Torr, 50Torr), the order is randomized for 3 intensities (10Torr, 20Torr, 35Torr) while 50Torr will always be last.