Impact of Gravity on Cardiac Hemodynamics
Effect of Intra-cardiac Hydrostatic Pressure Gradient in Cardiac Filling and Ejection
University Hospital, Caen
32 participants
Nov 22, 2023
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to define and compare pre-load dependance of the cardiac function according to the intracardiac hydrostatic gradient of pressure in healthy and diabetic populations. Participants will undergo 4 tilt angle and 4 lower body negative pressure intensities during which cardiovascular data will be assessed and a transthoracic echography will be performed.
Eligibility
Inclusion Criteria3
- Affiliated to the social security system
- Patient informed of the study and having signed an informed consent form
- Type 1 diabetes for at least 10 years followed at Caen University Hospital, equipped with a continous glucose monitoring system
Exclusion Criteria7
- Trained athletes (≥ 6 hours of sustained physical exercise >70% VO2max per week for > 6 months)
- Chronic cardiovascular disease or cardiovascular treatment
- Personal history of chemotherapy and/or thoracic radiotherapy
- Cerebral and/or spinal disease
- Inclusion of the subject in another biomedical research protocol of interventional type (during the study or in the 3 months prior to inclusion)
- Pregnant, breast-feeding or parturient women
- Adults under legal protection (guardianship, curators) or unable to express their consent or deprived of their freedom
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Interventions
Tilt of the patient at 4 angles (22°, 42°, 58° and 80°), the order is randomized for 3 angles (22°, 42°, 58°) while 80° will always be last.
The patient will undergo 4 level of LBNP (10Torr, 20Torr, 35Torr, 50Torr), the order is randomized for 3 intensities (10Torr, 20Torr, 35Torr) while 50Torr will always be last.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06190756