RecruitingNot ApplicableNCT06193499

A Study on the Effect of High-concentrated Platelet Rich Plasma (PRP) on Osteoarthritis in the Thumb Base.

Sponsor

Karolinska Institutet

Enrollment

90 participants

Start Date

Jan 17, 2024

Study Type

INTERVENTIONAL

Conditions

Osteoarthritis Thumb

Summary

This is a randomized double-blinded randomized comparison between injection of platelet rich plasma (PRP) and placebo for thumb basale osteoarthritis.

Eligibility

Inclusion Criteria3

Osteoarthritis in the thumb base
Radiological Eaton Littler class 1-3.
Clinical signs of thumb base osteoarthritis )pain at palpation of the CMC-1 joint and pain during provocation/grinding test).

Exclusion Criteria7

Rheumatoid arthritis
Ongoing infection in the hand or wrist
History of gout or pseudogout in the hand
Inability to co-operate with the follow-up protocol (language difficulties, severe psychiatric disorder, cognitive impairment, drug addiction).
Chronic pain syndrome / centralized pain.
Intra-articular injection in the affected joint within 6 months.
Eaton Littler class 4 (symptomatic STT joint osteoarthritis).

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