A Study on the Safety and Tolerability of RGL-193 in Patients With Advanced Parkinson's Disease

This study is testing the safety and tolerability of RGL-193, an experimental treatment, in people with advanced Parkinson's disease who have significant motor fluctuations — meaning their medication wears off during the day and causes periods of poor movement control. **You may be eligible if...** - You are between 45 and 70 years old - You have a confirmed Parkinson's disease diagnosis with at least 5 years of disease history - You are currently on levodopa (a standard Parkinson's medication) and clearly responding to it - You experience at least 3 hours per day of "off" time when your medication isn't working well - Your Parkinson's is at a moderate-to-advanced stage (Hoehn & Yahr stage ≥ 3) - Your motor symptoms are confirmed by a movement disorder evaluation (MDS-UPDRS part III score ≥ 30 in the off state) **You may NOT be eligible if...** - You have had deep brain stimulation or other brain surgery - Your symptoms have been unstable or your medications have changed in the last month - You have significant depression, dementia, or other neurological conditions Talk to your doctor to see if this trial is right for you.