Allogeneic Regenerative Islet Transplantation for the Treatment of Brittle Type 1 Diabetes Mellitus

This study tests a regenerative islet transplant approach for people with type 1 diabetes whose blood sugar remains dangerously uncontrolled despite taking insulin. It transplants insulin-producing cells (islets) from a donor pancreas into the patient to help restore natural insulin production. **You may be eligible if...** - You are 6–65 years old - You have type 1 diabetes with poor blood sugar control (HbA1c ≥7.5% or time in range <70%) despite intensive insulin therapy - Your body still produces some insulin (fasting C-peptide >0.1 nmol/L) - Your daily insulin dose is less than 0.5 units per kg of body weight - You are willing to use the study's blood glucose monitoring device **You may NOT be eligible if...** - You have no remaining insulin production - You have participated in another research study recently - You are pregnant or planning to become pregnant without using reliable contraception Talk to your doctor to see if this trial is right for you.