RecruitingNot ApplicableNCT06199193

Design of Personalised SupplemenTs Based on the Gut MicRobiota Through Artificial Intelligence for Alzheimer's Patients

Design of Personalised SupplemenTs Based on the Gut MicRobiota of Alzheimer Patients Through Network and Artificial Intelligence Analysis


Sponsor

Universidad Complutense de Madrid

Enrollment

120 participants

Start Date

Feb 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Studies indicate that the intestinal microbiota could have an implication in Alzheimer's disease; recently, a positive relationship has been established between levels of bacterial lipopolysaccharide (LPS) and cerebral amyloidosis and a negative relationship between the production of the chain fatty acid cuts butyrate by the intestinal microbiota and cerebral amyloidosis. Currently there is no effective treatment for Alzheimer's, but studies indicate that a healthy diet such as the Mediterranean diet and physical exercise delay the symptoms of this disease. For all these reasons, it is postulated that introducing changes in the intestinal microbiota through diet may be a new treatment or serve as an adjuvant treatment for Alzheimer's disease.


Eligibility

Min Age: 60 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study creates personalized nutritional supplement plans based on each person's gut bacteria and genetics to improve brain health and cognitive function in people with mild cognitive impairment or early dementia. It investigates whether targeting the gut-brain axis with tailored supplements can slow cognitive decline. **You may be eligible if...** - You are able to give written informed consent (or have a legal representative do so) - You meet the criteria for mild cognitive impairment or early-stage dementia - You have at least basic literacy (reading and writing) - You have adequate vision and hearing to complete study tests - You are fluent in the language used in the study **You may NOT be eligible if...** - You are unable to provide consent or have a representative do so - You cannot complete the cognitive tests due to sensory or language limitations - You do not meet the diagnostic criteria for the study's target condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTPersonalized diet

Personalized supplement designed by artificial intelligence based on the intestinal microbiota and incorporated into diets

DIETARY_SUPPLEMENTDietary counseling

Dietary advice will be provided to adapt the diet to the nutritional objectives and recommended intakes.


Locations(2)

Hospital Universitario Puerta de Hierro

Majadahonda, Madrid, Spain

Hospital Clínico Universitario Virgen de la Arrixaca

Murcia, Murcia, Spain

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NCT06199193


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