Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial

This trial (COURAGE) studies whether a structured exercise program can change the gut bacteria (microbiome) and immune system in young adults (under 50) with colorectal cancer who are receiving chemotherapy. **You may be eligible if...** - You were diagnosed with colon or rectal cancer between ages 18 and 50 - You are currently on chemotherapy or about to start - You currently exercise less than 90 minutes per week at moderate or vigorous intensity - You have medical clearance from your oncologist to exercise - You have no major surgery or radiation therapy planned for the next 12 weeks - You are able to communicate in English and travel to the Dana-Farber Cancer Institute (DFCI) for visits **You may NOT be eligible if...** - You currently exercise more than 90 minutes per week - You have unstable health conditions that make exercise unsafe - You are actively on a weight-loss diet or taking weight-loss drugs - You have another active cancer (other than basal cell skin cancer) Talk to your doctor to see if this trial is right for you.