RecruitingNCT06202235

Multifrequency MRE in Evaluation of Chronic Kidney Diseases

Multifrequency Renal MR Elastography in Evaluation of Chronic Kidney Diseases: Can Shear Stiffness Evaluate Renal Fibrosis in GFR-normal Patients?

Sponsor

Shengjing Hospital

Enrollment

200 participants

Start Date

Oct 10, 2022

Study Type

OBSERVATIONAL

Conditions

Chronic Kidney Disease(CKD)

Summary

Chronic Kidney Disease (CKD) is a major public health issue, leading to high mortality and the necessity for renal replacement therapy. Kidney fibrosis, resulting from chronic damage to kidney tissue, significantly determines CKD outcomes. Kidney biopsy, the gold standard for assessing fibrosis, is invasive and limited in its ability to reflect the heterogeneous nature of fibrosis. Consequently, there is growing interest in noninvasive methods, particularly Magnetic Resonance Elastography (MRE). MRE, which evaluates tissue stiffness, has shown potential for assessing kidney fibrosis. This study aims to use multifrequency MRE to assess renal fibrosis, focusing particularly on the early stages of CKD, to enhance understanding of its progression and relationship to clinical outcomes.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study uses an advanced MRI technique to measure the stiffness of kidneys in people with chronic kidney disease (CKD), with the goal of finding a non-invasive way to assess kidney health and reduce the need for biopsies. **You may be eligible if...** - You are an adult with chronic kidney disease (CKD), as defined by recent medical guidelines (either reduced kidney function or protein in the urine) - You have had a kidney MRI performed within 7 days of a kidney biopsy **You may NOT be eligible if...** - You have kidney cancer, polycystic kidney disease, a kidney transplant, or acute kidney failure - You have conditions that prevent an MRI (such as certain metal implants) - Your MRI images were poor quality - You have a severely deformed or enlarged kidney seen on MRI Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMagnetic Resonance Imaging

Both CKD patients and healthy volunteers will undergo a comprehensive MRI protocol, including T1-weighted imaging, T2-weighted imaging, Magnetic Resonance Elastography (MRE), Intravoxel Incoherent Motion (IVIM), Arterial Spin Labeling (ASL), T1 mapping, Blood Oxygen Level Dependent (BOLD), and Diffusion-Weighted Imaging (DWI) to evaluate liver and renal characteristics. For CKD patients, renal MRI will be performed within 7 days of the renal biopsy . Additionally, blood tests for creatinine and cystatin C, along with blood pressure measurements, will be collected.