A Study to Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)

This study is testing a new drug called vonsetamig in people with chronic kidney disease (CKD) who need a kidney transplant but are "highly sensitized" — meaning their immune system has developed so many antibodies that it is very difficult to find a compatible donor kidney. The drug aims to reduce those antibodies, making transplant possible. **You may be eligible if...** - You have chronic kidney disease requiring hemodialysis (dialysis through a machine) - You are on the kidney transplant waiting list and have a very high level of antibodies (cPRA ≥ 99.9%, or ≥ 98% with 5+ years on the waitlist) - Your blood and liver function meet requirements - You are willing and able to attend clinic visits **You may NOT be eligible if...** - You have an active cancer not in remission for at least 1 year - You have had your spleen removed - You received a stem cell transplant within the past 5 years - Your immune system function (IgG levels) is very low - You are currently on high-dose steroids or certain immune-suppressing drugs - You have significant nervous system disease Talk to your doctor to see if this trial is right for you.