RecruitingNot ApplicableNCT06206746

The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

A Prospective, Multicenter, Randomized, Pivotal Study of the May Health System in Transvaginal Ablation of Ovarian Tissue Under Ultrasound Guidance in Women With Infertility Due to Polycystic Ovary Syndrome


Sponsor

May Health

Enrollment

195 participants

Start Date

Mar 25, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

A Prospective, Multicenter, Randomized, Pivotal Study of the May Health System in Transvaginal Ablation of Ovarian Tissue under Ultrasound Guidance in Women with Infertility due to Polycystic Ovary Syndrome


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study tests a device called the May Health System to treat infertility in women with polycystic ovary syndrome (PCOS), a hormonal condition that disrupts ovulation. PCOS is one of the most common causes of infertility. The study compares this device to standard medication treatments. **You may be eligible if...** - You are between 18 and 40 years old - You have infertility related to irregular or absent ovulation - You have ultrasound or blood test evidence of PCOS (enlarged ovaries, many small follicles, or elevated male hormones) **You may NOT be eligible if...** - You have other causes of infertility (such as blocked tubes or male factor) - You have previously had ovarian surgery - You have uncontrolled diabetes or thyroid disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEMay Health System

The intervention includes the short-term use of the May Health System, which is comprised of three elements: (1) the May Health Needle-Catheter Ablation Device (NCAD) (the Device) a 16 gauge echogenic needle including a bipolar temperature-controlled RF ablation catheter which is clipped and secured onto a vaginal ultrasound probe; (2) the May Health Adapter which is clipped onto the ultrasound probe; and (3) the May Health Generator: a bipolar radiofrequency (RF) ablation platform utilizing the single use May Health NCAD for ovarian tissue ablation. Once the patient is under conscious sedation, the physician guides the May Health system transvaginally with the use of a transvaginal ultrasound. Once the May Health device is safely and securely positioned, the physician will deliver radio frequency energy inside the ovary in order to ablate the tissue.


Locations(23)

HRC Fertility - Encino

Encino, California, United States

UCSF Center for Reproductive Health

San Francisco, California, United States

University of South Florida

Tampa, Florida, United States

The IVF Center

Winter Park, Florida, United States

SIU School of Medicine, Reproductive Endocrinology & Infertility Center

Springfield, Illinois, United States

University of Iowa Health Care

Iowa City, Iowa, United States

Cypress Medical Research Center

Wichita, Kansas, United States

Johns Hopkins Fertility Center

Lutherville, Maryland, United States

UMass Memorial Medical Center / UMass Chan Medical School

Worcester, Massachusetts, United States

IVF Michigan, P.C.

Bloomfield Hills, Michigan, United States

Washington University Fertility and Reproductive Medicine Center

St Louis, Missouri, United States

University Reproductive Associates, PC

Hasbrouck Heights, New Jersey, United States

University of Rochester, Strong Fertility Center

Rochester, New York, United States

Reach Fertility

Charlotte, North Carolina, United States

UNC Fertility

Raleigh, North Carolina, United States

University of Cincinnati

Cincinnati, Ohio, United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Penn State College of Medicine

Hershey, Pennsylvania, United States

Penn Fertility Care

Philadelphia, Pennsylvania, United States

Prisma Health - Upstate

Greenville, South Carolina, United States

UT Health San Antonio

San Antonio, Texas, United States

Baylor Scott & White Medical Center

Temple, Texas, United States

UW Health Generations Fertility Care

Middleton, Wisconsin, United States

View Full Details on ClinicalTrials.gov

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NCT06206746


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