RecruitingNot ApplicableNCT06207136

Microbiome and Diet in Parkinson's Disease

Canadian Parkinson's Microbiome Initiative: A Pilot Phase 2 Feasibility Randomized Controlled Trial of the MIND Diet in Parkinson's Disease


Sponsor

University of British Columbia

Enrollment

40 participants

Start Date

Dec 3, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia. Research has shown that eating components of Mediterranean diets are associated with a 30% lower risk to develop PD and a 40% lower mortality rate in those living with PD. Diet may influence the gut and microbiomes, thus may affect PD risk and progression. This study will examine how easy it will be to adhere to a certain type of diet for 18 months and what changes may occur in the gut microbiome and in PD symptoms on a specific diet during that time. The study will involve in-person study visits at UBC as well as online diet coaching sessions and online group cooking classes over Zoom. This is a randomized study, meaning that participants will be assigned by chance to either the Mediterranean-style diet group or the standard diet group for the duration of the 18 months. This pilot study will also examine recruitment rates and retention, in order to prepare for a larger future study.


Eligibility

Min Age: 40 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study examines how diet and gut bacteria (the microbiome) are connected to Parkinson's disease symptoms and progression. Participants will follow a specific diet and attend cooking and coaching sessions over 18 months while researchers track their gut health and neurological changes. **You may be eligible if...** - You have a confirmed clinical diagnosis of Parkinson's disease - You are between 40 and 80 years old and cognitively stable (no dementia) - You have been on a stable Parkinson's medication for at least one month - You can travel to UBC for 6 in-person visits and attend video sessions - You have computer/internet access at home and are proficient in English **You may NOT be eligible if...** - You have a related but different condition (e.g., multiple system atrophy) - You have severe swallowing difficulties or major dietary restrictions that conflict with the study - You do not have reliable internet or cannot commit to the session schedule Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMediterranean-style diet

Coaching in the intervention diet group will promote higher consumption of healthier foods and cooking oils, while discouraging processed foods.


Locations(1)

UBC Pacific Parkinson's Research Centre

Vancouver, British Columbia, Canada

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NCT06207136


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