Proteomic Guided First-line Precision Treatment of Renal Clear Cell Carcinoma

Exclusion Criteria20

• Patients with any of the following conditions will be excluded from the trial:
• Patients who have received the following medical interventions in the four weeks prior to treatment:
• Radiation, surgery, chemotherapy, immunotherapy or molecular targeted therapy for tumors
• To participate in other clinical studies of drug therapy
• Live attenuated vaccine history
• Previously received PD-1/PD-L1 monoclonal antibody, CTLA-4 antibody(cytolytic T lymphocyte-associated antigen) or other immunotherapy;
• Previously received targeted therapy;
• Definite brain/meningeal metastasis;
• Patients who received systemic treatment with corticosteroids (\> 10 mg daily prednisone or equivalent) or other immunosuppressive drugs within 14 days prior to enrollment;
• Any active autoimmune disease or history of autoimmune disease (including but not limited to: autoimmune hepatitis, interstitial pneumonia, uveitis, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism), or known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation;
• Severe disturbances (CTCAE, Common Terminology Criteria for Adverse Events\> Class 2) occurred within 4 weeks prior to administration of the study drug;Baseline chest imaging suggests active pulmonary inflammation, signs and symptoms of infection (unexplained fever \>38.5 degrees) within 14 days prior to first use of the study drug, or the need for oral or intravenous antibiotic treatment;
• Patients with clinically significant bleeding symptoms or definite bleeding tendency within 3 months prior to treatment, or with arteriovenous thrombosis events occurring within 6 months prior to treatment;
• Active cardiovascular disease, such as myocardial infarction, severe/unstable angina, or New York Heart Association Class III or IV congestive heart failure, was present in the 6 months prior to treatment.
• Have had other malignancies in the past 5 years (basal cell carcinoma of the skin that has been cured, except carcinoma in situ of the breast and carcinoma in situ of the cervix);
• Have multiple factors that affect oral medication (such as inability to swallow, chronic diarrhea, and intestinal obstruction);
• Known to have active tuberculosis;
• HIV antibody positive, active hepatitis B or C (HBV, HCV);
• Is known to be allergic to the investigational drug or any excipients thereof, or has had a severe allergic reaction to other monoclonal antibodies;
• Pregnant or lactating women and women of childbearing age do not take reliable contraceptive measures;
• In the investigator's judgment, there is a concomitant medical condition (such as poorly controlled high blood pressure, severe diabetes, neurological or psychiatric illness, etc.) or any other condition that seriously endangers the subject's safety, may confuse the study results, or may interfere with the subject's completion of the study.