Proteomic Guided First-line Precision Treatment of Renal Clear Cell Carcinoma

This trial is testing a personalized treatment approach for kidney cancer (clear cell renal cell carcinoma) that has spread or cannot be removed with surgery. Instead of giving all patients the same treatment, doctors will analyze proteins in each patient's tumor to figure out which drug combination is most likely to work best for them. This is called proteomic-guided precision medicine. **You may be eligible if...** - You are 18 to 75 years old - You have been diagnosed with kidney cancer (clear cell type) that has spread or cannot be surgically removed - Your cancer has not been treated with any systemic (whole-body) therapy before - There is at least one measurable area of cancer visible on a scan - You are in reasonably good physical health and able to carry out daily activities - Your blood counts, kidney, and liver function are within acceptable ranges - Tumor tissue samples are available for testing **You may NOT be eligible if...** - You have already received systemic treatment for your kidney cancer - Your overall health or organ function is too poor to safely receive treatment - Your expected survival is less than 3 months - You have a condition that would prevent safe participation Talk to your doctor to see if this trial is right for you.