EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation
EXCLAMATORY: EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation With Exercise CapacitY Longitudinal Study
Virginia Commonwealth University
50 participants
Dec 26, 2024
OBSERVATIONAL
Conditions
Summary
Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).
Eligibility
Inclusion Criteria6
- Age ≥18 years
- Diagnosis of paroxysmal AF
- Left ventricular ejection fraction ≥50%
- Scheduled for catheter ablation
- Able to speak, hear, and read English
- Willing and able to provide informed consent
Exclusion Criteria15
- Persistent or permanent AF
- Prior ablation (catheter based or surgical) for AF
- Significant sinus node dysfunction
- Implanted pacemaker or defibrillator
- Contraindication to or inability to complete cardiovascular magnetic resonance study
- Contraindication to or inability to complete exercise testing
- Chronic kidney disease with estimated glomerular filtration rate \<30 mL/min/1.73m2
- Severe left ventricular hypertrophy
- Unrelated cardiomyopathy that is expected to limit exercise capacity, including but not limited to:
- Hypertrophic cardiomyopathy
- Cardiac amyloidosis
- Constrictive pericarditis
- Pulmonary arterial hypertension
- Prior cardiac surgery
- Active pregnancy
Interventions
Complete the Self- Report Evaluation-Duke Activity Status Index
Complete the Self- Report Evaluation, Atrial Fibrillation Effect on Quality of Life Questionnaire
Cardiopulmonary exercise test (CPET)
Transthoracic echocardiogram at rest and immediately following peak exercise during CPET
Ambulatory cardiac rhythm assessment
Cardiovascular magnetic resonance (CMR) study at rest and during two stages of submaximal exercise (ExeCMR)
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06212791