RecruitingNCT06212791

EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

EXCLAMATORY: EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation With Exercise CapacitY Longitudinal Study


Sponsor

Virginia Commonwealth University

Enrollment

50 participants

Start Date

Dec 26, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how the heart's left upper chamber (the left atrium) recovers after a procedure called catheter ablation for atrial fibrillation (AF), which is an irregular heartbeat. Researchers will use MRI scans of the heart — both at rest and during exercise — to look at how the heart mechanics improve after ablation. **You may be eligible if...** - You are 18 or older - You have been diagnosed with paroxysmal AF (intermittent irregular heartbeat that comes and goes) - Your heart's pumping strength is normal (ejection fraction at least 50%) - You are scheduled to have catheter ablation for your AF - You are able to speak, read, and understand English **You may NOT be eligible if...** - You have persistent or permanent AF (not the intermittent type) - You have had a previous ablation procedure for AF - You have a pacemaker or defibrillator implanted - You have significant kidney disease (eGFR below 30) - You are pregnant - You have certain other heart conditions such as hypertrophic cardiomyopathy, cardiac amyloidosis, or pulmonary hypertension - You have had prior heart surgery - You are unable to complete an MRI or exercise test Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALSelf- Report Evaluation-Duke Activity Status Index

Complete the Self- Report Evaluation-Duke Activity Status Index

BEHAVIORALSelf- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire

Complete the Self- Report Evaluation, Atrial Fibrillation Effect on Quality of Life Questionnaire

DIAGNOSTIC_TESTCardiopulmonary exercise test (CPET)

Cardiopulmonary exercise test (CPET)

DIAGNOSTIC_TESTTransthoracic echocardiogram

Transthoracic echocardiogram at rest and immediately following peak exercise during CPET

DIAGNOSTIC_TESTAmbulatory cardiac rhythm assessment

Ambulatory cardiac rhythm assessment

DIAGNOSTIC_TESTCardiovascular magnetic resonance (CMR)

Cardiovascular magnetic resonance (CMR) study at rest and during two stages of submaximal exercise (ExeCMR)


Locations(1)

Virginia Commonwealth University

Richmond, Virginia, United States

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NCT06212791


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