Radiation Therapy in Unresectable Gall Bladder Cancer

This trial is testing whether radiation therapy (used alongside chemotherapy) can help treat gallbladder cancer that is too advanced to be removed by surgery. Gallbladder cancer is often diagnosed late when it has already grown into nearby blood vessels or the liver. Researchers want to see if radiation can shrink or control the tumor in patients who have already had some chemotherapy. **You may be eligible if...** - You are over 18 years old - You have gallbladder cancer confirmed by biopsy - Your cancer has not spread to distant organs - Your cancer is locally advanced — invading nearby blood vessels, the liver, or causing bile duct blockage - You had stable disease or partial response after 3 months of gemcitabine-based chemotherapy - You are in good enough health to tolerate chemotherapy and radiation - Your blood counts, kidney, and liver function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has spread to distant organs (metastatic) - Your overall health is too poor to safely receive chemotherapy or radiation - The radiation cannot be safely delivered due to the tumor's location relative to healthy tissue Talk to your doctor to see if this trial is right for you.