The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer

This trial is testing whether metformin (a diabetes medication with known protective properties for the kidneys) can prevent kidney damage caused by cisplatin, a commonly used chemotherapy drug for bladder cancer. Cisplatin can harm the kidneys, and this study wants to see if adding metformin can reduce that risk in non-diabetic patients. **You may be eligible if...** - You are 18 to 65 years old - You do not have diabetes - You have been diagnosed with bladder cancer and have not yet received chemotherapy - Your kidney function is in the normal range (eGFR above 60) **You may NOT be eligible if...** - You have a history of lactic acidosis (a serious buildup of acid in the blood) - You are taking other medications that can damage the kidneys (such as NSAIDs, aminoglycosides, or vancomycin) - You have heart failure, recent heart attack, or circulatory collapse - You have severe liver disease - You have a serious or active infection - You drink alcohol - You have respiratory failure - Your cancer has spread to other organs (metastatic) Talk to your doctor to see if this trial is right for you.