Reverse-Engineering of Exclusive Enteral Nutrition (RE-EEN) in Crohn's Disease: A Multi-Center Trial

This trial is studying a dietary treatment for children and young adults with active Crohn's disease — a chronic condition causing inflammation in the digestive tract. Called exclusive enteral nutrition (EEN), this approach involves replacing all regular food with a specially formulated liquid diet for a period of time, which can calm gut inflammation. This study is testing a smoothie-based version to make it more acceptable and practical for young patients. **You may be eligible if...** - You are 8 to 21 years old - You have been diagnosed with Crohn's disease within the past 24 months - Your Crohn's disease is currently active (based on a standard pediatric activity score of 10 or above) - You have elevated inflammatory markers in your blood or stool - You (or a parent/guardian if you are a minor) can give informed consent **You may NOT be eligible if...** - You have had surgery for Crohn's disease - You have perianal Crohn's disease (disease around the anal region) - You have recently used steroids, or recently changed your immunosuppressant dose - You have previously received biologic medications, exclusive enteral nutrition, dietary therapy, or antibiotics specifically for Crohn's - You are currently hospitalized due to the severity of your disease - You have known food allergies to any smoothie ingredients - You are unwilling to give informed consent Talk to your doctor to see if this trial is right for you.