Adjunctive Treatment With L-methylfolate for Treatment-Resistant Generalized Anxiety Disorder: a Pilot Study

This trial is testing whether adding L-methylfolate (a form of the B vitamin folate) to standard antidepressant treatment improves outcomes in patients with depression that has not responded well to existing medications. L-methylfolate is thought to help the brain produce mood-regulating chemicals more effectively. **You may be eligible if...** - You have been diagnosed with major depressive disorder - Your depression has not adequately responded to at least one antidepressant - You are 18 or older - You are currently being treated with an antidepressant medication **You may NOT be eligible if...** - You have bipolar disorder, schizophrenia, or active psychosis - You have a known allergy to folate or methylfolate supplements - You are currently using drugs or alcohol in a way that would interfere with the study - You are pregnant or planning to become pregnant during the study Talk to your doctor to see if this trial is right for you.