RecruitingNot ApplicableNCT06220396

CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study

Sponsor

Mayo Clinic

Enrollment

80 participants

Start Date

Jan 22, 2026

Study Type

INTERVENTIONAL

Conditions

Healthy

Summary

The purpose of this study is to evaluate pulmonary capillary wedge pressure (PCWP) and other hemodynamic measurements at rest and during exercise in healthy volunteers across the age spectrum.

Eligibility

Min Age: 30 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring heart pressures and blood flow at rest and during exercise in apparently healthy adults across a range of ages, using invasive hemodynamic monitoring, to better understand how the heart's capacity changes over a lifetime. The data will help researchers identify early signs of heart stress that may not yet cause symptoms. You may be eligible if you are a healthy adult with no history of heart failure, no significant heart or lung disease, and are willing and able to undergo an exercise test with invasive pressure monitoring and an MRI. Participation involves a series of cardiovascular assessments including monitored exercise testing and imaging. This summary was prepared using AI to help patients understand this research.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURERight Heart Catheterization with Hemodynamics and Limited Echocardiogram

Right Heart Catheterization (RHC) with Hemodynamics and Limited Echocardiogram is an invasive procedure that involves insertion of a catheter through a blood vessel in the neck, groin, or arm to the right side of the heart. Hemodynamic measurements such as the blood pressure inside the veins, heart, and arteries as well as measurements of blood flow and how much oxygen is in the blood will be completed during the catheterization procedure. It is a way to see how well the heart is working during your procedure. During the RHC procedure a limited echocardiogram, using ultrasound waves, will be collected to evaluate the structure and function of the heart. All measurements will be conducted at rest and during exercise using a supine cycle ergometer

PROCEDUREMagnetic Resonance Imaging (MRI)

MRI is a medical imaging technique that uses a magnetic field and computer-generated radio waves to create detailed images of the organs and tissues in your body. CMR Imaging will assess myocardial structure, function, and fat content. An additional limited MRI sequence of the the abdomen and one sequence in the thigh will be used to evaluate for visceral adipose tissue (VAT) as a measurement of body composition.

PROCEDUREDual X-ray absorptiometry (DEXA) scan

A DEXA scan measures the amount of fat in the body using an x-ray that measures bone, calcium and fat.