Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)

This observational study is collecting blood samples and clinical data from people with colorectal cancer or advanced colon polyps, as well as from healthy individuals, to develop a multi-marker blood test (using DNA, proteins, and other signals) that can detect colorectal cancer early. This is not a treatment trial — it is a research study focused on finding better screening tools. **You may be eligible if...** - You are 18 or older with confirmed colorectal adenocarcinoma or advanced adenoma (case group), OR - You are a healthy individual at general or high risk for colorectal cancer, confirmed cancer-free by colonoscopy (control group) - You are willing to provide blood samples and consent to research use of your data **You may NOT be eligible if...** - You have had another cancer (other than non-melanoma skin cancer) - You have had prior treatment for colorectal cancer or advanced polyps - You have a hereditary colorectal cancer syndrome (e.g., Lynch syndrome, FAP) - You have had a blood transfusion in the past 2 weeks, or organ/bone marrow transplant - You are pregnant - You are currently on anti-tumor or anti-infection medications Talk to your doctor to see if this trial is right for you.