Efficacy and Safety of Linperlisib in Relapsed/Refractory Large Granular T Lymphocytic Leukemia

This study is testing whether a drug called linperlisib can treat a rare type of blood cancer called T-cell large granular lymphocytic leukemia (T-LGLL), which often causes low blood counts including severe anemia or low neutrophils, and typically affects middle-aged to older adults. **You may be eligible if...** - You are 18 years old or older - You have been diagnosed with T-cell large granular lymphocytic leukemia (T-LGLL) - You have symptoms that require treatment, such as low hemoglobin, dangerously low neutrophils, enlarged spleen, or autoimmune disease linked to your leukemia - Your T-LGLL has failed or you could not tolerate a first standard treatment - Your liver, kidney function, and overall health are adequate **You may NOT be eligible if...** - You have another blood cancer or lymphoma - You have had a prior organ or stem cell transplant - You have active infections requiring treatment, or active hepatitis B, C, or HIV - You are pregnant or breastfeeding - You have a history of severe lung problems like pulmonary fibrosis - You have had another cancer within the last 5 years (with some exceptions) Talk to your doctor to see if this trial is right for you.