Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study

This study is testing whether psilocybin — a compound found in certain mushrooms — can help people reduce or stop cannabis use in those with moderate to severe cannabis use disorder (CUD). This is a proof-of-concept study to see if the approach is feasible and promising enough to test further. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with at least moderate cannabis use disorder - You want to reduce or stop your cannabis use - You are in good general medical health - You have a stable residence and can commit to the full study period - You are fluent in English **You may NOT be eligible if...** - You have a personal or close family history of schizophrenia, bipolar disorder, or other psychotic disorders - You have a history of panic disorder or seizure disorders - You are dependent on any substance other than cannabis or tobacco - You have used psychedelic drugs (LSD, psilocybin, ayahuasca, etc.) more than 5 times in your life or in the past year - You are taking antipsychotic medications, benzodiazepines, or tricyclic antidepressants - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.