Adjuvant vs Surgery Only in Early-stage Recurrent NPC

This trial is comparing two approaches for treating nasopharyngeal carcinoma (NPC — a type of head and neck cancer) that has come back after initial radiation treatment: surgery alone versus surgery followed by additional anti-cancer therapy. **You may be eligible if...** - You have confirmed recurrent nasopharyngeal carcinoma - Your recurrent cancer is early-stage (rT1, rT2, or limited rT3) - You have had only one prior course of radiation - It has been at least 6 months since completing radiation before the recurrence - You recently had endoscopic surgery with clear (negative) margins - You are between 18 and 75 years old with no distant spread **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have had more than one course of radiation previously - Your overall health is too poor to tolerate additional treatment - You have uncontrolled illnesses or are participating in another trial Talk to your doctor to see if this trial is right for you.