RecruitingNot ApplicableNCT06235242

GT201 Injection in Combination with Teraplizumab Injection for Treatment of Patients with Non-small Cell Lung Cancer

A Single-arm Clinical Study of Autologous Tumor-Infiltrating Lymphocyte (GT201 Injection ) in Combination with Teraplizumab Injection for Treatment of Patients with Non-small Cell Lung Cancer


Sponsor

Grit Biotechnology

Enrollment

20 participants

Start Date

Feb 2, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a single arm, open design aimed at evaluating the safety and tolerability of Autologous Tumor-Infiltrating Lymphocyte (GT201 injection ) in combination with teraplizumab injection for treatment of patients with non-small cell lung cancer,while evaluating pharmacokinetic characteristics and efficacy assessment to determine the optimal biological dose (OBD).


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a combination of a cell therapy (GT201, a type of engineered immune cell therapy) with an immunotherapy drug (teraplizumab) for patients with non-small cell lung cancer (NSCLC). **You may be eligible if...** - You are 18 to 70 years old - You have non-small cell lung cancer that has progressed - You are in reasonably good general health - Your expected survival is at least 12 weeks - Your cancer has at least one measurable tumor on imaging **You may NOT be eligible if...** - You have uncontrollable cancer-related pain - You have a known mental illness, alcohol dependency, or substance abuse issues - You are pregnant, breastfeeding, or planning to become pregnant within 1 year of treatment - You have received another experimental treatment within 4 weeks before starting this trial Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALGT201 injection in combination with teraplizumab injection

GT201 injection in combination with teraplizumab injection for treatment of patients with non-small cell lung cancer


Locations(3)

Beijing Gobroad Hospital

Beijing, Beijing Municipality, China

Shanghai East Hospital

Shanghai, Shanghai Municipality, China

Shanghai GoBroad Cancer Hospital

Shanghai, Shanghai Municipality, China

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NCT06235242


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