RecruitingNot ApplicableNCT06237868

rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

The Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation on Impulse Control Disorders in Parkinson's Disease Patients on Dopamine Replacement Therapy.


Sponsor

West Virginia University

Enrollment

20 participants

Start Date

May 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing repetitive transcranial magnetic stimulation (rTMS) — a non-invasive brain stimulation technique — as a treatment for impulse control disorders in people with Parkinson's disease. Impulse control problems (like compulsive gambling, shopping, or eating) are a known side effect of some Parkinson's medications. **You may be eligible if...** - You have a confirmed diagnosis of Parkinson's disease - You have been diagnosed by a clinician with an impulse control disorder or related behavior (such as punding or dopamine dysregulation syndrome) - You are currently taking dopamine-replacement medication for Parkinson's - Your depression score (BDI) is 14 or lower - Your cognitive score (MoCA) is 20 or higher **You may NOT be eligible if...** - You have a history of seizures or epilepsy - You have had a stroke, brain tumor, or significant brain injury - You have significant depression (BDI score of 14 or higher) or severe cognitive impairment - You are pregnant - You have metal implants in your head (except dental fillings) - You have had TMS treatment within the past year - You use substances or medications that significantly lower the seizure threshold Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICErTMS Active

The participants undergo Active rTMS, approximately 10-15 min and then complete tasks and questionnaires.

DEVICErTMS Sham

The participants undergo Sham rTMS, approximately 10-15 min and then complete tasks and questionnaires.


Locations(1)

West Virginia University Hospitals

Morgantown, West Virginia, United States

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NCT06237868


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