Monitoring of Heart to Guide Myocardial Injury Patients to Wean From Ventilation
A Randomized Controlled Study on Continuous Monitoring of Cardiac Index Variability to Guide Patients With Perioperative Myocardial Injury to Wean From Mechanical Ventilation
Peking University People's Hospital
200 participants
Feb 19, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this prospective randomized controlled clinical trail is to explore the value of integrating continuous cardiac index variability indicators with existing weaning standards to guide perioperative myocardial injury patients weaning. The main question it aims to answer is: whether the introduction of new indicators for weaning standards can improve the success rate of weaning. Treatment that'll be given to participants is: the cardiac index (CI) is continuously monitored from 15-30 minutes prior to the start of the weaning from ventilation. Participants who increase their CI by more than 30% can have their tracheal intubation removed. Researchers will compare the weaning success rate of CI group and control group.
Eligibility
Inclusion Criteria5
- Perioperative myocardial injury patients
- Age\>18 years;
- Acute Physiology and Chronic Health Evaluation II (APACHEII)\>8 ;
- The weaning process has not yet started after surgery;
- Expected postoperative cumulative mechanical ventilation time\>24 hours.
Exclusion Criteria6
- Pregnancy or childbirth less than 42 days;
- Patients and their families are unable to cooperate with treatment;
- The cumulative actual mechanical ventilation time after surgery is ≤ 24 hours;
- Interruption of mechanical ventilation treatment due to death or other reasons before entering the weaning process;
- Patients who retain artificial airways after weaning;
- Patients who plan to start non-invasive mechanical ventilation treatment immediately after weaning.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
During the spontaneous breathing test phase, the cardiac index (CI) is continuously monitored from 15-30 minutes prior to the start of the test. Patients who have successfully completed the spontaneous breathing test and increased their CI by more than 30% and meet ordinary weaning indications can have their tracheal intubation removed.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06240104