RecruitingPhase 4NCT06245109

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Sponsor

Northwestern University

Enrollment

180 participants

Start Date

Feb 26, 2024

Study Type

INTERVENTIONAL

Conditions

Knee Osteoarthritis

Summary

This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have a knee Xray, (optional) MRIs of the brain and knee, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to try to predict which participants will respond to the treatment.

Eligibility

Min Age: 41 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Celecoxib, a drug called Duloxetine, and others for people with knee osteoarthritis. The study is currently recruiting participants at 1 location. People eligible for this study include aged 41 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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