RecruitingPhase 1NCT06245746

UCMSC-Exo for Chemotherapy-induced Myelosuppression in Acute Myeloid Leukemia

A Single-center, Prospective Trial of the Safety and Efficacy of UCMSC-Exo in Consolidation Chemotherapy-induced Myelosuppression in Patients With Acute Myeloid Leukemia After Achieving Complete Remission


Sponsor

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Enrollment

9 participants

Start Date

Feb 26, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of the study is to explore the safety and efficacy of UCMSC-Exo in consolidation chemotherapy-induced myelosuppression in patients with acute myeloid leukemia after achieving complete remission.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether tiny particles called exosomes derived from umbilical cord mesenchymal stem cells can help the bone marrow recover more quickly after chemotherapy in patients with acute myeloid leukemia (AML) — a blood cancer — who are in remission and receiving consolidation (follow-up) chemotherapy. Bone marrow suppression after chemo can lead to dangerous drops in blood cell counts. **You may be eligible if...** - You are between 18 and 60 years old - You have been diagnosed with acute myeloid leukemia (AML, excluding a subtype called M3/APL) - Your AML is in complete remission after initial treatment - You are about to begin consolidation chemotherapy (follow-up chemo to keep the cancer in remission) - Your general health and organ function are adequate **You may NOT be eligible if...** - You have AML subtype M3 (also known as APL) - You have active serious infections - You have serious liver, kidney, or heart problems - You are pregnant or breastfeeding - You have had a prior stem cell transplant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALumbilical cord derived mesenchymal stem cells exosomes (UCMSC-Exo)

UCMSC-Exo will be infused intravenously.


Locations(1)

Wuhan Union Hospital

Wuhan, Hubei, China

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NCT06245746


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