In Vitro Organoid Drug Sensitivity-Guided Treatment for Advanced Pancreatic Neuroendocrine Tumor

This study is testing whether growing a patient's own tumor cells in the lab as a 3D model (called an organoid) and testing different drugs on it can help doctors choose the most effective chemotherapy regimen for people with advanced pancreatic neuroendocrine tumors (pNETs) — a rare type of pancreatic cancer. **You may be eligible if...** - You are between 18 and 75 years old - You have a confirmed advanced or metastatic pancreatic neuroendocrine tumor - Surgery to remove the cancer is not possible or won't achieve a cure - You can provide fresh tumor tissue (from biopsy or surgery) for lab testing - Your general health is reasonably good (ECOG 0–2) with at least 6 months expected survival **You may NOT be eligible if...** - You have had another cancer in the past 5 years (except treated skin cancer) - You have had a serious heart attack or major cardiovascular event in the past year - You have severe liver or kidney problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.