The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

This study explores how psilocybin (the active compound in certain mushrooms) affects the way people with depression think about themselves. Researchers believe that depression involves too much negative self-focused thinking, and psilocybin may help shift that pattern. Participants will receive psilocybin in a controlled, supervised clinical setting. **You may be eligible if...** - You are between 18 and 55 years old - You have been diagnosed with moderate or greater major depressive disorder - Your depression has lasted at least 3 months - You score at least 18 on a standard depression scale - You are able to give informed consent **You may NOT be eligible if...** - You have a personal or family history of psychosis, schizophrenia, or bipolar disorder - You are currently taking certain psychiatric medications - You have active suicidal intent - You have a serious heart condition or other major medical illness - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.