RecruitingPhase 2NCT06248671

Prophylactic Treatment With Atorvastatin for Episodic Migraine.

EpisodicStatinMig. A Multicentre, Triple Blind, Placebo Controlled, Parallel Group Study of Atorvastatin in Episodic Migraine


Sponsor

St. Olavs Hospital

Enrollment

450 participants

Start Date

May 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be confirmed in a larger, multicenter, randomized controlled parallel group study. In addition it will be investigated whether 1) there is an effect of a daily dose of 20mg Atorvastatin, 2) whether the favorable side effect profile, seen in previous studies, can be confirmed, and whether it is even better with the smaller dose, and 3) estimating the cost of Atorvastatin treatment, considering cost of medicine, cost of acute attack medicine, and cost of lost worktime.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Atorvastatin 20mg, a drug called Atorvastatin 40mg, and others for people with episodic migraine. The study is currently recruiting participants at 6 locations. People eligible for this study include aged 18 Years to 65 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAtorvastatin 40mg

Each tablet will be taken once daily for 84 days.

DRUGPlacebo

Each tablet will be taken once daily for 84 days

DRUGAtorvastatin 20mg

Each tablet will be taken once daily for 84 days.


Locations(6)

Haukeland University Hospital

Bergen, Norway

University Hospital, Akershus

Lørenskog, Norway

Oslo University Hospital, Rikshospitalet

Oslo, Norway

Oslo University Hospital, Ullevål

Oslo, Norway

University Hospital Northern Norway

Tromsø, Norway

St. Olavs hospital

Trondheim, Norway

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NCT06248671


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